My lab is a space for science, creativity, education, and diversity. All these dimensions are at the same level in the lab. I believe that to be solid scientists we must be well educated and trained, be creative, develop as reliable colleagues, learn how to be mentors and educators, and appreciate the value of diversity because we are all diverse. Please, learn more about our research here and here, our current team and past members here, my educational philosophy here, and my diversity philosophy here. (Jimena Giudice).
Summary of our science
Alternative splicing is a posttranscriptional mechanism that explains how individual genes can produce more than one transcript due to the inclusion or exclusion of specific regions originating multiple protein isoforms with diverse features. More than 90% of human genes undergo alternative splicing. This high prevalence raises the question of how developmental stage- and tissue-specific splicing influence protein function and how this regulation occurs.
In the lab we are interested on how alternative splicing regulates the expression of trafficking and membrane dynamics proteins in normal development and diseases. A second angle of the lab is how alternative splicing impacts on the functions of these proteins and thus in internal cell architecture and physiology.