March 2024. Jess Cote received a 3-year F32 postdoctoral fellowship from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). She will use the award to study the impact of specific alternative splicing events on skeletal muscle development. Congrats Jess!!

March 2024. Most of the lab attend and presente at the McAllister (MHI) / Integrative Vascular Biology (IVB) Training Program Symposium.

December 2023. Our very own Jess Cote won the Extra Mile Award for Postdoctoral Fellows in the Cell Biology and Physiology Department. Joined award with Zac in Doug Phanstiel’s lab. Congrats Jess!!! So well deserved!

December 2023. Jess Cote received one of the awards from the Core Facilities Advocacy Committee’s (CFAC) voucher program, School of Medicine, University of North Carolina at Chapel Hill. These funds will support some of her histology experiments. Congrats Jess!


November 2023. Olivia A. Perez joins our lab as an undergraduate research assistant! Welcome on board, Olivia!

October 2023. Our most recent paper is out in iScience! Read the full article here

October 2023. Jimena Giudice was invited as Keynote Speaker to the 33rd Keck Annual Research Conference in Houston.

August 2023. Gabby Gentile has been awarded a F31 predoctoral fellowship from the NIH/NHLBI. Congrats Gabby! We are so, so proud of you!

August 2023. Gabby Gentile presented her work in the Basic Cardiovascular Sciences Conference (American Heart Association) in Boston!

July 2023. Aubri presented her talk at the EDGE Genomics Program Final Symposium. Thanks Gabby Gentile for having been a great mentor for Aubri!

July 2023. Aaliyah presented her summer work in a poster format to the lab. Thanks Jess and Eric for having been great mentors for Aaliyah!

July 2023. Breakfast lab celebration! So many good news to celebrate:

  • Gabby Bais T32 IVB training grant
  • Gabby Gentile Dissertation Completion Fellowship
  • Jess Cote SPLENDOR Pilot grant
  • Aubri Bishop and Aaliyah Bryant Summer Internships
  • NIGMS supplement award for a new -80C freezer for the lab
  • Jimena Giudice appointed in NIH study section (permanent member) for three years

June 2023. Aubri Bishop joins the lab as an EDGE-Genomics summer scholar and will be working with Gabby Gentile. Welcome on board Aubri!

June 2023. Gabby Gentile selected for a Dissertation Completion Fellowship (2023-2024) from The Graduate School at The University of North Carolina at Chapel Hill. Congrats Gabby!

June 2023. Gabby Bais selected for the UNC IVB T32 training program and funding.

June 2023. The lab received a supplement award from our R01 (R01GM130866, NIH-NIGMS) to purchase a new -80C freezer. Thanks NIH-NIGMS for all your support!

Funding Information — FDI Lab

May 2023. Jessica Cote obtained a P&F award from SPLENDOR-NC to support some studies within her research project. Congrats Jess!!

May 2023. Gabrielle Bais joins the lab as a Cell Biology and Physiology (CBP) graduate student. Welcome on board Gabby!

April 2023. Jimena Giudice receives a CAREER award from the National Science Foundation (NSF).  The project entitled, “Mechanotransduction, transcription, and alternative splicing in cell biology” has been awarded for five years. The Faculty Early Career Development (CAREER) Program is a Foundation-wide activity that offers the National Science Foundation’s most prestigious awards in support of early-career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization. Activities pursued by early-career faculty should build a firm foundation for a lifetime of leadership in integrating education and research. More info here

April 2023. Matheus Sadovsky presented his undergrad research at the Annual Symposium. Congrats Matheus, we are very proud of you. And a big Thanks to his bench mentor Jessica Cote.

March 2023. Jimena Giudice named Associate Director of Graduate Studies in the Cell Biology and Physiology (CBP) curriculum.

Department of Cell Biology and Physiology

March 2023. Jimena Giudice promoted to Associate Professor (with tenure) in the Department of Cell Biology and Physiology starting on March 1st. CONGRATS!

February 2023. Rachel Szymanski joined the lab for her third rotation. Welcome on board Rachel!

January 2023. Claire Sykes joined the lab as an undergraduate researcher. Welcome on board Claire!

November 2022. Hannah Wiedner successfully defended her Ph.D. thesis. CONGRATULATIONS DR. WIEDNER! We are so, so proud of you!

November 2022. Gabby Bais finished her rotation and presented her work! We will miss you Gabby but we wish you all the best in the next rotations!

We thank Emma Hinkle and Gabby Gentile, both graduate students in the lab, for being great mentors for Gabby Bais.

October 2022. Conference time!

September 2022. Emma Hinkle successfully defended her Ph.D. thesis. CONGRATULATIONS DR. HINKLE! We are so, so proud of you!

September 2022. Emma Hinkle’s paper is published in Communications Biology!

  • Hinkle ER, Blue RE, Tsai, Y-H, Combs M, Davi J, Coffey AR, Boriek A, Taylor JM, Parker J, Giudice J*. (2022). Mechanical stretching induces global transcriptional and posttranscriptional transitions and changes in SR proteins in muscle cells. Communications Biology. 5 (1): 987. doi: 10.1038/s42003-022-03915-7

September 2022. Hannah Wiedner won the Terry Magnuson Award jointly with Sarah Brotman (Mohlke Lab)!

The Terry Magnuson Award recognizes outstanding graduating students in the two curricula administered by the Department of Genetics.

Congrats Hannah! We are so proud of you!

September 2022. Jimena Giudice presented her seminar at CBP

August 2022. Lunch celebration of so many good news:

  • Gabby and Eric’s co-first author paper published in FASEB Journal
  • Hannah’s first author paper published in FEBS journal
  • Emma’s first author paper accepted for publication in Communications Biology
  • And Hannah’s mentorship award

Congrats to all of us!!

August 2022. Gabby Bais joined the lab for her Fall rotation. Welcome on board Gabby!

July 2022. Gabby Gentile, Jenn Gamarra, Nic Engels, and Eric Blue co-first author paper published in the FASEB Journal! Wonderful team effort!

June 2022. Hannah Wiedner‘s first author paper published in FEBS journal. This work revealed how a chromatin-modifying enzyme SETD2 contributes to regulation of alternative splicing and metabolism in muscle cells.

  • Wiedner HJ, Torres EV, Blue RE, Tsai YH, Parker J, Giudice J. (2022). SET domain containing 2 (SETD2) influences metabolism and alternative splicing during myogenesis. FEBS Journal. In press. Read full article here

June 2022. Gabby Gentile selected for a platform oral presentation in the RNA Society Annual Meeting from the RNA Society in Boulder, Colorado. So proud of you, Gabby!

June 2022. Hannah Wiedner presented at the Southeastern Society for Developmental Biology about the Shadow A Scientist outreach program with other fellow executive board members Rafia and Odessa. Learn more about their program at

May 2022. Hannah Wiedner was awarded a Science Mentoring Award form the UNC-Chapel Hill Office of Graduate Education. Well deserved! Congrats Hannah!

If you would like to learn more about the program that Hannah co-founded:

April 2022. Emma Hinkle and Hannah Wiedner co-first author paper has been published in the RNA journal and they were invited for a “Meet the first authors” editorial feature.

  • Hinkle ER#, Wiedner HJ#, Torres E, Jackson M, Black AJ, Blue RE, Harris SE, Guzman BB, Gentile GM, Lee EY, Tsai Y-H , Parker J, Dominguez D, Giudice J. (2022). Alternative splicing regulation of membrane trafficking genes during myogenesis. RNA, 28 (4): 523-540. # co-first authors.

January 2022. Hannah Wiedner was awarded funding for a UNC ImPACT internship at StrideBio. Congrats Hannah!

December 2021. Eric Blue won the Staff Excellence Award from the Department of Cell Biology and Physiology ! Our best lab manager ever! Congrats Eric! We are so proud of you and so grateful to you!

December 2021. Gabby Gentile selected to participate in the GENETICS Peer Review Training Program from the Genetic Society of America (GSA). Congrats Gabby! We are sure this will significantly contribute to your education as a strong scientist and colleague!.

December 2021. Emma Hinkle and Tasneem Essader co-first author and Gabby Gentile second author paper published in Skeletal Muscle Journal.

October 2021. Jessica Cote joins our lab as a postdoctoral associate. Welcome on board Jess!

August 2021.  Gabby Gentile‘s abstract selected for an oral platform in the Cold Spring Harbor Lab Meeting “Eukaryotic mRNA Processing

June 2021.  Hannah Wiedner‘s review published in  Nature Structural and Molecular Biology. Review is entitled: “It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation”. Take a look here!

April 2021. Emma Hinkle awarded F31-NIH (NIAMS) predoctoral fellowship. Congrats Emma!

November 2020. Jimena Giudice awarded a Jefferson-Pilot Fellowship in Academic Medicine from UNC-Chapel Hill, School of Medicine. The Jefferson-Pilot Fellowships in Academic Medicine are provided to promising junior faculty within the UNC-Chapel Hill School of Medicine, and conveys the School’s confidence in his/her future.

July 2020. We received a supplement award from our R01 (R01GM130866, NIH-NIGMS) to purchase an electroporation transfection equipment.

June 2020. Gabby Gentile passed her Oral Exam as a Ph.D. student of the GMB curriculum. Congratulations Gabby!

April 2020. Gabby Gentile and Nicole Rivera both got awarded GRFP fellowships from the National Science Foundation (NSF) to fund their graduate training! Congrats! We are so proud of you.

March 2020. We published a new research article in the Journal of Cell Biology. Great collaboration with Amy Gladfelter at UNC-Chapel Hill and Marko Horb at MBL! Take a look here

January 2020. We published a magazine article for The Scientist entitled: “Alternative Splicing Provides a Broad Menu of Proteins for Cells” and is authored by Gabrielle M. Gentile, Hannah J. Wiedner, Emma R. Hinkle, and Jimena Giudice. Take a look here

2019 November. Hannah Wiedner passed her Oral Exam as a Ph.D. student of the GMB curriculum. Congratulations Hannah!

2019 October. Emma Hinkle passed her Oral Exam as a Ph.D. student of the GMB curriculum. Congratulations Emma!

2019 October. The entire lab participated in the 2019 Symposium on RNA Biology XIII: RNA Tool and Target. Adam presented a a wonderful short talk, Jimena chaired the “RNA processing session”, and Gabby, Hannah W, Emma, Hannah C, and Eddie presented amazing posters!

2019 September.  Gabby Gentile, Emma Hinkle, Hannah Wiedner and Jimena Giudice participated in the Annual Retreat of the Department of Genetics and the GMB and BCB graduate programs in Wilmington.  Jimena presented a talk and Emma and Hannah presented their posters.

2019 August. Adam Black, Emma Hinkle, Hannah Wiedner and Jimena Giudice participated in the Cold Spring Harbor Laboratory meeting “mRNA Eukaryotic Processing”. Hannah’s abstract was selected for a platform presentation. Adam and Emma presented their work in the poster sessions.

2019 July. Nicole Rivera joins the lab as a PREP scholar. Welcome Nicole!

2019 July. Adam Black receives prestigious F32 Postdoctoral Fellowship from the National Heart, Lung, and Blood Institute (NHLBI). Congrats Adam!

2019 July.  Our review is published!

Black AJ, Gamarra JR, Giudice J. (2019). More than a messenger: Alternative splicing as a therapeutic target. BBA – Gene Regulatory Mechanisms. in press

2018 June. Gabby Gentile appointed in T32 training grant from MiBio . Congrats, Gabby. We are so proud of you!

Image result for mibio unc

2019 May. Hannah Wiedner receives prestigious Predoctoral Fellowship from the National Science Foundation (NSF). Congrats Hannah!

2019 May. Gabrielle Gentile joins the lab as a GMB Ph.D. student! Welcome on board Gabby!!!

April 2019. Jimena Giudice awarded a Career Development Award from the American Heart Association. This award provides three years of funding (USD 210,000).

2019 May. Lab lunch to celebrate numerous awards and events: R01-NIGMS, AHA Career Development Award to Jimena Giudice, NSF to Hannah Wiedner, poster award to Jennifer Gamarra, selected talks for Emma Hinkle, Hannah Wiedner, Jennifer Gamarra, and Nichlas Engels, we say good bye to our great undergrads Micaela Jackson, Isabel Hoerr, Jackie Davi, and Becky Chen. Beautiful lunch moment.

2019 April. Undergrads Jackie Davi, Eddie Torres, Micaela Jackson and Hannah Cafaro presented their work in the Undergraduate Student Symposium. They did a great job presenting their posters!. We especially thank also their direct mentors: Hannah Wiedner, Adam Black and Emma Hinkle.

2019 April. Jenn Gamarra won Poster Award in the Women in Science (WinS) Symposium. Congrats Jenn!

2019 March. Adam Black presented a poster in the IVB/McAllister Heart Institute symposium. He did a great job presenting his work!

2019 February. We are grateful and honored to have been awarded our first RO1 from the National Institutes of Health (NIH).

2019 February. Our review is published!

Hinkle ER, Wiedner HJ#, Black AJ#, Giudice J. (2019). RNA processing in skeletal muscle biology and disease. Transcription10 (1): 1-20. [#equal contribution]

2018 December.- Holiday lunch! Great time!!!

2018 November.- Congratulations to Jenn Gamarra for wining the most outstanding poster award in Cell Biology in the ABRCMS 2018 in Indianapolis!

2018 November.- Jenn Gamarra, Ennessa Curry, Elise Sloey, and Gabby Gentile presented their posters in the BBSP poster session.

2018 November.- Gabby Gentile and Elise Sloey join the lab for their second BBSP rotation. Welcome!!

2018 October.-  Our paper is out!

Blue RE, Koushik A, Engels NM, Wiedner HJ, Cooper TA, Giudice J. (2018). Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology. International Journal of Biochemistry and Cell Biology

2018 August.- Ennessa Curry re-joins the lab now as a First-year graduate student for her first rotation. Welcome back Ennessa!!!

2018 August.- Hannah Cafaro joins the lab as a work-study student. Welcome Hannah!

2018 August.- Hannah Wiedner and Emma Hinkle passed their GMB written exams! Congratulations!!!

2018 August.- Eddie Torres presented his poster in the Undergraduate Research Symposium. UNC Chapel Hill. Emma Hinkle and Hannah Wiedner were his mentor in this project.

2018 July.- Jimena Giudice presented an oral contribution in the “Second International Caparica Conference in Splicing”, Caparica, Portugal.

2018 June.- Jimena Giudice presented a short talk in the Gordon Research Conference “Lysosomes and Endocytosis”, Andover, NH.

2018 June.- Jimena Giudice and Ennessa Curry invited to present a workshop about how to keep good lab notebooks to the new UNC-PREP Scholars

2018 June.- Hannah Wiedner and Emma Hinkle appointed in T32 training grants from MiBio and GMB, respectively. Congrats!!!!! We are so proud of you!

2018 June.- Jennifer Gamarra joins the lab as a PREP-UNC scholar. Welcome Jennifer!

2018 May.- Ennessa Curry graduated from the PREP-UNC program and won the third place award for her talk presentation in the final symposium. Congrats Ennessa, we are so proud of you!

2018 May.- Review article is published in the Journal of Cell Science!: How alternative splicing affects membrane trafficking by RE Blue, Curry EG#, Engels NM#, Lee EY and Giudice J.  [#equal contribution]

2018 May.- Eddie Torres joins the lab as a Summer Chancellor Scholar. Welcome, Eddie!

2018 May.- Micaela Jackson joins the lab as an undergraduate research assistant. Welcome on board!

2018 April.- Hannah Wiedner and Emma Hinkle  join the lab for their Ph.D. theses. We are so happy and honored to have you both on board!

2018 April.- Becky Chen and Jessica Harrison presented their posters in the Undergraduate Research Symposium. They did it great!

2018 April.- Jimena Giudice awarded a Basil O’Connor Starter Scholar Research Award from the March of Dimes Foundation. Wonderful news for the lab!

2018 March.- Ennessa Curry accepted the offer from UNC-Chapel Hill for Graduate School. Congratulations, Ennessa!

2018 February.- Emma Hinkle joins the lab as a rotation student (Spring). Welcome Emma!

2018 January.- Adam Black joins the lab as a postdoctoral research associate. Welcome Adam!

2017 October.- Review article published in Nature Reviews Molecular Cell Biology “Alternative splicing as a regulator of development and tissue identity” (Baralle & Giudice) was included in the Nature Web-collection entitled “mRNA splicing: 40 years on”

2017 October.- We participated in the 2017 Symposium on RNA Biology XII: RNA Tool and Target. We presented four posters!

1. Hannah Wiedner won the Best Poster Award in the category Basic RNA Biology! Congrats Hannah!

2. Isabel Hoerr, Becky Chen, and Hannah Wiedner got travel awards. Congrats!


2017 September.- Jimena Giudice presented a seminar in the International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy, hosted by Dr. Francisco Baralle.

2017 August.- Hannah Wiedner joins the lab for her first rotation as a first year BBSP graduate student. Welcome Hannah!

2017 August.- Marvin Meza Jarquin, Jackie Davi, and Jessica Harrisson join the lab as undergraduate research assistant. Welcome!!!

2017 August.- We say good bye to Susan Ngo. All the best for your new step as a Pharmacy graduate student, dear Susan.

2017 July.- Ennessa Curry joins the lab as a UNC-Chapel Hill PREP (Postbaccalaureate Research Education Program) Scholar. Welcome Ennessa!

2017 July.- Review article is published in Nature Reviews Molecular Cell Biology!: “Alternative splicing as a regulator of development and tissue identity“. Baralle & Giudice. And the review is mentioned in the cover!


2017 June.- Collaborative review article with Joan Taylor (UNC) has been published in Current Opinion in Pharmacology: “Muscle as a paracrine and endocrine organ”. Giudice & Taylor.

2017 February.- We got awarded a Pilot & Feasibility Grant from the Nutrition and Obesity Center (NORC) – The University of North Carolina at Chapel Hill. This award will support our studies on: “Alternative splicing and nutrient uptake: effects on striated muscle homeostasis during postnatal development”

2017 January.- Welcome Mazin Nour, Isabel Hoerr, and Nic Engels  to the lab!

2016 December.- Jimena awarded Junior Faculty Development AwardThe University of North Carolina at Chapel Hill. This award will partially support one of our projects in the lab!

2016 December.- We contributed to the collaborative study published in Cell Death and Disease! “Heme oxygenase-1 in the forefront of a multi-molecular network that governs cell-cell contacts and filopodia-induced zippering in prostate cancer”

2016 November.- Cell Reports paper si published!


2016 October.– Jimena’s paper with Baylor – UNC double affiliation has been published in Scientific Reports!

2016 October.– Susan Ngo joined the lab! Welcome!

2016 September.– Welcome Becky and Alex to the lab! We are starting our experiments!


2016 July.-  Eunice Lee  joins the lab. Welcome, on board Eunice!

2016 July.- Our lab is almost ready for experiments! and Eunice will join us at the end of July!


2016 May.- Jimena’s abstract has been selected for a platform presentation at the Weinstein Cardiovascular Development and Regeneration Conference 2016

2016 May.- Welcome Eric! Our best Lab Manager!

2016 March.– Jimena joins UNC! Here’s the lab


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