Principal Investigator, Assistant Professor

Department of Cell Biology and Physiology, School of Medicine

McAllister Heart Institute

2016 March –

Affiliation Ph.D. programs:

1) Cell Biology and Physiology curriculum

2) Genetics and Molecular Biology (GMB) curriculum

Contact information

6340B Medical Biomolecular Research Building

111 Mason Farm Rd., Chapel Hill, NC 27599

Phone: 919-962-6260


Education and training

Postdoctoral Fellow, Baylor College of Medicine, Houston, TX, 8/2011-2/2016

–  American Heart Association Postdoctoral Fellow

–  PEW Charitable Trusts Postdoctoral Fellow

Visiting Fellow, Max Planck Institute for Biophysical Chemistry, Germany, 10/2008-3/2009

–  European Molecular Biology Organization (EMBO) Short-term Fellow

Ph.D. Biological Chemistry, University of Buenos Aires, Argentina, 12/2007-3/2011

–  National Scientific and Technical Research Council (CONICET Argentina), Predoctoral Fellow

M. Sc. comparable. Chemistry, University of Buenos Aires, Argentina, 8/2002-3/2007

M. Ed. comparable. Chemistry Education, University of Buenos Aires, Argentina, 3/2001-5/2005

Selected publications [* denotes corresponding author]

  • Hinkle ER, Blue RE, Tsai, Y-H, Combs M, Davi J, Coffey AR, Boriek A, Taylor JM, Parker J, Giudice J. (2022). Mechanical stretching induces global transcriptional and posttranscriptional transitions and changes in SR proteins in muscle cells. Communications Biology. 5 (1): 987. doi: 10.1038/s42003-022-03915-7.
  • Gentile GM#, Gamarra J#, Engels N#, Blue RE#, Hoerr I, Wiedner HJ, Hinkle ER, Cote JL, Leverence E, Mills A, Herring L, Tan X, Giudice J*. (2022). The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis. FASEB Journal. 36 (8): e22441. doi: 10.1096/fj.202101627RR. # co-first authors.
  • Hinkle ER#, Wiedner HJ#, Torres E, Jackson M, Black AJ, Blue RE, Harris SE, Guzman BB, Gentile GM, Lee EY, Tsai Y-H , Parker J, Dominguez D, Giudice J*. (2022). Alternative splicing regulation of membrane trafficking genes during myogenesis. RNA, 28 (4): 523-540. # co-first authors.
  • Hinkle ER#, Essader TO#, Gentile GM, Giudice J*. (2021). ViaFuse: Fiji macros to calculate skeletal muscle cell viability and fusion index. Skeletal Muscle, 11 (1): 28. doi: 10.1186/s13395-021-00284-3. # co-first authors.
  • Wiedner HJ, Giudice J*. (2021). It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation. Nature Structure and Molecular Biology, 28 (6): 465-473
  • Musicant AM, Parag-Sharma K, Gong W, Sengupta M, Chatterjee A, Henry EC, Tsai Y-H, Hayward MC, Sheth S, Betancourt R, Hackman TG, Padilla RJ, Parker JS, Giudice J, Flaveny CA, Hayes DN, Amelio AL. (2021). CRTC1-MAML2 establishes a PGC1α-IGF1 circuit that confers vulnerability to PPARγ inhibition. Cell Reports. 34 (8): 108768.
  • Smith JA#, Curry EG#, Blue RE#, Roden C, Dundon SER, Rodriguez-Vargas A, Jordan DC, Chen X, Lyons SM, Crutchley J, Anderson P, Horb M, Gladfelter AS*, Giudice J*. (2020). FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. Journal of Cell Biology, 219 (4): e201911129. # co-first authors.
  • Huang, Sachdeva M, Xu E, Robinson, TJ, Luo L, Ma Y, Williams N, Lopez O, Cervia LD, Yuan F, Qin X, Zhang D, Owzar K, Gokgoz N, Seto A, Okada T, Singer S, Andrulis IL, Wunder J, Lazar AJ, Rubin BP, Pipho K, Mello SS, Giudice J, Kirsch DJ. (2020). The long non-coding RNA NEAT1 promotes sarcoma metastasis by regulating RNA splicing pathways. Molecular Cancer Research. doi: 10.1158/1541-7786.MCR-19-1170.
  • Black AJ, Gamarra JR, Giudice J*. (2019). More than a messenger: alternative splicing as a therapeutic target. BBA – Gene Regulatory Mechanisms, 1862 (11-12): 194395. doi: 10.1016/j.bbagrm.2019.06.006.
  • Hinkle ER, Wiedner HJ#, Black AJ#, Giudice J*. (2019). RNA processing in skeletal muscle biology and disease. Transcription,10 (1): 1-20.
  • Blue RE, Koushik A, Engels N, Wiedner HJ, Cooper TA, Giudice J*. (2018). Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology. International Journal of Biochemistry and Cell Biology  pii: S1357-2725(18)30227-9.
  • RE Blue, Curry EG#, Engels NM#, Lee EY and Giudice J*.  (2018). How alternative splicing affects membrane trafficking. Journal of Cell Science, 131(10): pii: jcs216465. # equally contributed.
  • Baralle FE, Giudice J*. (2017). Alternative splicing as a regulator of development and tissue identity. Nature Reviews Molecular Cell Biology, 8(7): 437-451.
  • Giudice J*, Taylor JM*. (2017). Muscle as a paracrine and endocrine organ. Current Opinion in Pharmacology, 34: 49-55.
  • Giudice J*, Loehr JA, Rodney GG, Cooper TA*. (2016). Alternative splicing of four trafficking genes regulates myofiber structure and skeletal muscle physiology. Cell Reports, 17 (8): 1923-33.
  • Giudice J, Xia Z, Li W, Cooper TA. (2016). Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1. Scientific Reports, 6:35550. doi:10.1038/srep35550.
  • Wang ET, Ward AJ, Cherone JM, Giudice J, Wang TT, Treacy DJ, Lambert NJ, Freese P, Saxena T, Cooper TA, Burge CB. (2015). Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins. Genome Research, 25(6): 858-71.
  • Pedrotti S, Giudice J, Dagnino-Acosta A, Knoblauch M, Mo Q, Hicks J, Hamilton S, Cooper TA. (2015). The RNA-binding protein Rbfox1 regulates adult skeletal muscle function. Human Molecular Genetics, 4 (8): 2360-74.
  • Giudice J, Xia Z, Wang ET, Ruddy MA, Ward AJ, Kalsotra A, Wang W, Wehrens XHT, Burge CB, Li W, Cooper TA. (2014). Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nature Communications, 5: 3603. doi: 10.1038/ncomms4603.
  • Giudice J*, Cooper TA*. (2014). RNA-binding proteins in heart development. Adv Exp Med Biol, 825: 389-429.
  • Giudice J, Jares-Erijman EA, Leskow FC. (2013). Insulin receptor membrane retention by a traceable chimeric mutant. Cell Communication and Signaling, 11(1): 45. doi: 10.1186/1478-811X-11-45.
  • Giudice J, Jares-Erijman E, Leskow FC. (2013). Endocytosis and intracellular dissociation rates of human insulin-insulin receptor complexes by quantum dots in living cells. Bioconjugate Chemistry, 24(3): 431-42.
  • Giudice J, Barcos LS, Guaimas FF, Penas A, Giordano L, Jares-Erijman EA, Leskow FC. (2013). Insulin and IGF-II endocytosis and signaling via insulin receptor B. Cell Communication and Signaling, 11(1): 18. doi: 10.1186/1478-811X-11-18.

Magazine Article

  • Gentile GM, Wiedner HJ, Hinkle ER, Giudice J*. (2020). Alternative splicing provides a broad menu of proteins for cells. The Scientist, 34 (10): 38-43.

Honors and awards

  • UNC-Chapel Hill, School of Medicine, Jefferson Pilot Award, 11/2020 – 10/2025
  • American Heart Association, Career Development Award, 4/2019 – 3/2022
  • NIH-NIGMS, R01 research grant, 3/2019 – 3/2024
  • March of Dimes Foundation, Basil O’Connor Starter Scholar Award, 4/2018 – 3/2020
  • NC TraCS, Pilot Grant $50K, 8/2018 – 1/2020
  • Nutrition Obesity Research Center (NORC-UNC), Pilot & Feasibility Grant, 4/2017 – 3/2018
  • The University of North Carolina at Chapel Hill, Junior Faculty Development Award, calendar year 2017
  • American Heart Association, Postdoctoral Fellowship, 7/2014 – 2/2016
  • Pew Charitable Trusts, Postdoctoral Fellowship, 7/2012 – 2/2016
  • European Molecular Biology Organization (EMBO), Short Term Fellowship, 12/2008 – 2/2009
  • German Academic Exchange Service (DAAD), Short Term Fellowship, 11/2008 – 03/2009, kindly declined
  • National Scientific and Technical Research Council (CONICET – Argentina), Pre-doctoral Fellowship, 4/2008 – 3/2011
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