Members of the lab appear in bold

# denotes equal contribution and * denotes corresponding author


  • Wiedner HJ, Blue RE, Sadovsky M, Mills CA, Wehrens XT, Herring LE, Giudice J*. (2023). RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis. iScience. 26 (11): 108258. doi: 10.1016/j.isci.2023.108258. Read the full article here


  • Hinkle ER, Blue RE, Tsai, Y-H, Combs M, Davi J, Coffey AR, Boriek A, Taylor JM, Parker J, Giudice J*. (2022). Mechanical stretching induces global transcriptional and posttranscriptional transitions and changes in SR proteins in muscle cells. Communications Biology. 5 (1): 987. doi: 10.1038/s42003-022-03915-7. Read the full article here

– Invited to contribute to the “Behind the Papers” section of the Nature blog . Read the blog article here

  • Gentile GM#, Gamarra J#, Engels N#, Blue RE#, Hoerr I, Wiedner HJ, Hinkle ER, Cote JL, Leverence E, Mills A, Herring L, Tan X, Giudice J*. (2022). The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis. FASEB Journal. 36 (8): e22441. doi: 10.1096/fj.202101627RR.
  • Wiedner HJ, Torres EV, Blue RE, Tsai YH, Parker J, Giudice J*. (2022). SET domain containing 2 (SETD2) influences metabolism and alternative splicing during myogenesis. FEBS Journal. 289 (21): 6799-6816. Read full article here
  • Hinkle ER#, Wiedner HJ#, Torres E, Jackson M, Black AJ, Blue RE, Harris SE, Guzman BB, Gentile GM, Lee EY, Tsai Y-H , Parker J, Dominguez D, Giudice J*. (2022). Alternative splicing regulation of membrane trafficking genes during myogenesis. RNA, 28 (4): 523-540.

– Co-first authors were invited for a “Meet the first authors” editorial feature


  • Hinkle ER#, Essader TO#, Gentile GM, Giudice J*. (2021). ViaFuse: Fiji macros to calculate skeletal muscle cell viability and fusion index. Skeletal Muscle, 11 (1): 28. doi: 10.1186/s13395-021-00284-3.
  • Wiedner HJ, Giudice J*. (2021). It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation. Nature Structure and Molecular Biology, 28 (6): 465-473.  Link

– Featured in the journal website

  • Musicant AM, Parag-Sharma K, Gong W, Sengupta M, Chatterjee A, Henry EC, Tsai Y-H, Hayward MC, Sheth S, Betancourt R, Hackman TG, Padilla RJ, Parker JS, Giudice J, Flaveny CA, Hayes DN, Amelio AL. (2021). CRTC1-MAML2 establishes a PGC1α-IGF1 circuit that confers vulnerability to PPARγ inhibition. Cell Reports. 34 (8): 108768.


  • Smith JA#, Curry EG#, Blue RE#, Roden C, Dundon SER, Rodriguez-Vargas A, Jordan DC, Chen X, Lyons SM, Crutchley J, Anderson P, Horb M, Gladfelter AS*, Giudice J*. (2020) FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. The Journal of Cell Biology, 219 (4): e201911129. Link
  • Gentile GM, Wiedner HJ, Hinkle ER, Giudice J*. (2020) Alternative splicing provides a broad menu of proteins for cells. The Scientist, 34 (10): 38-43. [MAGAZINE ARTICLE]

– Featured in the magazine issue

– Mentioned in the UNC-Chapel Hill Health news

– Mentioned in the news from the Dept. Molecular Biophysics and Biochemistry at Yale University

  • Huang, Sachdeva M, Xu E, Robinson, TJ, Luo L, Ma Y, Williams N, Lopez O, Cervia LD, Yuan F, Qin X, Zhang D, Owzar K, Gokgoz N, Seto A, Okada T, Singer S, Andrulis IL, Wunder J, Lazar AJ, Rubin BP, Pipho K, Mello SS, Giudice J, Kirsch DJ. (2020). The long non-coding RNA NEAT1 promotes sarcoma metastasis by regulating RNA splicing pathways. Molecular Cancer Research. doi: 10.1158/1541-7786.MCR-19-1170.


  • Black AJ, Gamarra JR, Giudice J*. (2019). More than a messenger: alternative splicing as a therapeutic target. BBA – Gene Regulatory Mechanisms, 1862 (11-12): 194395. doi: 10.1016/j.bbagrm.2019.06.006.
  • Hinkle ER, Wiedner HJ#, Black AJ#, Giudice J*. (2019). RNA processing in skeletal muscle biology and disease. Transcription, 10 (1): 1-20.
  • Leonardi DB, Anselmino N, Brandani JN, Jaworski FM, Páez AV, Mazaira G, Meiss RP, Nuñez M, Nemirovsky SI, Giudice J, Galigniana M, Pecci A, Gueron G, Vazquez E, Cotignola J. (2019). Heme oxygenase 1 impairs glucocorticoid receptor activity in prostate cancer. International Journal of Molecular Sciences, 20 (5): pii: E1006. doi: 10.3390/ijms20051006.


  • Blue RE, Koushik A, Engels N, Wiedner HJ, Cooper TA, Giudice J*. (2018). Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology. International Journal of Biochemistry and Cell Biology  pii: S1357-2725(18)30227-9. doi: 10.1016/j.biocel.2018.10.004.
  • Blue RE, Curry EG#, Engels NM#, Lee EY, Giudice J*. (2018). How alternative splicing affects membrane trafficking. The Journal of Cell Science, 131(10): pii: jcs216465. doi: 10.1242/jcs.216465.
  • Gueron G, Anselmino N, Chiarella P, Ortiz EG, Lage Vickers S, Paez AV, Giudice J, Contin MD, Leonardi D, Jaworski F, Manzano V, Strazza A, Montagna DR, Labanca E, Cotignola J, D Accorso N, Woloszynska-Read A, Navone N, Meiss RP, Ruggiero R, Vazquez E. (2018). Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis. Cell Death and Disease, 9 (2): 140. doi: 10.1038/s41419-017-0147-8.


  • Baralle FE, Giudice J*. (2017). Alternative splicing as a regulator of development and tissue identity. Nature Reviews Molecular Cell Biology, 8 (7): 437-451.

– Mentioned in the cover

– Included in the Series: “RNA processing and modifications”

– Included in the Nature Web collection entitled “mRNA splicing: 40 years on”.

  • Giudice J*, Taylor JM*. (2017). Muscle as a paracrine and endocrine organ. Current Opinion in Pharmacology, 34: 49-55.


  • Paez AV, Pallavecini C, Schuster F, Valacco MP, Giudice J, Ortiz EG, Anselmino N, Labanca E, Binaghi M, Salierno M, Martí MA, Cotignola JH, Woloszynska-Read A, Bruno L, Levi V, Navone N, Vazquez ES, Gueron G. (2016). Heme oxygenase-1 in the forefront of a multi-molecular network that governs cell–cell contacts and filopodia-induced zippering in prostate cancer. Cell Death and Disease, 7 (12): e2527. doi: 10.1038/cddis.2016.433.
  • Giudice J*, Loehr JA, Rodney GG, Cooper TA*. (2016). Alternative splicing of four trafficking genes regulates myofiber structure and skeletal muscle physiology. Cell Reports, 17 (8): 1923-33.

 Press release :  1. STAT news -2. ALN magazine -3. UNC-Chapel Hill  -4. -5. Bionity -6. Biosciences -7. Science Daily 8. EurekAlert -9. HealthCanal -10. MedicalXpress

  • Giudice J, Xia Z, Li W, Cooper TA. (2016). Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1. Scientific Reports, 6:35550. doi:10.1038/srep35550.

Before Dr. Giudice joined UNC-Chapel Hill


  • Labanca E, De Luca P, Gueron G, Páez A, Moiola CP, Massillo C, Porretti J, Giudice J, Zalazar F, Navone N, Vazquez E, De Siervi A. (2015). Association of HO-1 and BRCA1 Is Critical for the Maintenance of Cellular Homeostasis in Prostate Cancer. Molecular Cancer Research, 3 (11): 1455-64.

 Article selected for the Highlights’s section

  • Wang ET, Ward AJ, Cherone JM, Giudice J, Wang TT, Treacy DJ, Lambert NJ, Freese P, Saxena T, Cooper TA, Burge CB. (2015). Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins. Genome Research, 25 (6): 858-71.
  • Pedrotti S, Giudice J, Dagnino-Acosta A, Knoblauch M, Mo Q, Hicks J, Hamilton S, Cooper TA. (2015). The RNA-binding protein Rbfox1 regulates adult skeletal muscle function. Human Molecular Genetics, 4 (8): 2360-74.


  • Giudice J, Xia Z, Wang ET, Ruddy MA, Ward AJ, Kalsotra A, Wang W, Wehrens XHT, Burge CB, Li W, Cooper TA. (2014). Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nature Communications, 5: 3603. doi: 10.1038/ncomms4603.

Press release: 1. Baylor College of Medicine -2. ScienceDaily

  • Giudice J*, Cooper TA*. (2014). RNA binding proteins in heart development. Adv Exp Med Biol 825: 389-429.
  • Gueron G*, Giudice J, Elguero B, Valacco P, Paez A, Toscani AM, Jaworski F, Leskow FC, Cotignola J, Marti M, Binaghi M, Navone N, Vazquez E*. (2014). HO-1: the mastermind behind the morphology and the adhesive behavior of prostate cancer cells. Oncotarget, 5 (12): 4087-102.


  • Giudice J, Jares-Erijman EA, Leskow FC. (2013). Insulin receptor membrane retention by a traceable chimeric mutant. Cell Communication and Signaling, 11(1): 45. doi: 10.1186/1478-811X-11-45.
  • Giudice J, Jares-Erijman E, Leskow FC. (2013). Endocytosis and intracellular dissociation rates of human insulin-insulin receptor complexes by quantum dots in living cells. Bioconjugate Chemistry, 24 (3): 431-42.
  • Giudice J, Barcos LS, Guaimas FF, Penas A, Giordano L, Jares-Erijman EA, Leskow FC. (2013). Insulin and IGF-II endocytosis and signaling via insulin receptor B. Cell Communication and Signaling ,11 (1): 18. doi: 10.1186/1478-811X-11-18.
  • Pistone Creydt V, Fletcher SJ, Giudice J, Bruzzone A, Chasseing NA, Gonzalez EG, Sacca PA, Calvo JC. (2013). Human adipose tissue from normal and tumoral breast regulates the behaviour of mammary epithelial cells. Clinical Translational Oncology, 15 (2): 124-31.


  • Elguero B, Gueron G, Giudice J, Toscani AM, De Luca P, Zalazar F, Leskow FC, Meiss R, Navone N, De Siervi A, Vazquez E. (2012). Heme oxygenase 1 (HO-1) impairs androgen receptor transcription through STAT3 signaling in prostate cancer. Neoplasia, 14 (11): 1043-56.


  • Ferrando M#, Gueron G#, Elguero B, Giudice J, Salles A, Leskow FC, Jares-Erijman EA, Colombo L, Meiss R, Navone N, De Siervi A, Vazquez E. (2011). Heme oxygenase 1 (HO-1) challenges the angiogenic switch in prostate cancer. Angiogenesis, 14 (4): 467-79.


  • Rossetti MV, Granata BX, Giudice J, Parera VE, Batlle A. (2008). Genetic and biochemical studies in Argentinean patients with variegate porphyria. BMC Medical Genetics, 9 (1): 54. doi: 10.1186/1471-2350-9-54.
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